Radiolytic transformation of rotenone with potential anti-adipogenic activity

Chul-Hong Park; Byung Yeoup Chung; Seung Sik Lee; Hyoung-Woo Bai; Jae Young Cho; Cheorun Jo; Tae Hoon Kim

doi:10.1016/j.bmcl.2012.12.003

Radiolytic transformation of rotenone with potential anti-adipogenic activity

Bioorg Med Chem Lett. 2013 Feb 15;23(4):1099-103. doi: 10.1016/j.bmcl.2012.12.003. Epub 2012 Dec 20.

Authors

Chul-Hong Park¹, Byung Yeoup Chung, Seung Sik Lee, Hyoung-Woo Bai, Jae Young Cho, Cheorun Jo, Tae Hoon Kim

Affiliation

¹ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea.

PMID: 23317572
DOI: 10.1016/j.bmcl.2012.12.003

Abstract

Radiolytic transformation of the isoflavonoid rotenone (1) with γ-irradiation afforded two new degraded products, rotenoisins A (2) and (3). The structures of the two new rotenone derivatives were elucidated on the basis of spectroscopic methods. The new products 2 and 3 exhibited significantly enhanced inhibitory activities against pancreatic lipase and adipocyte differentiation in 3T3-L1 cells when compared to parent rotenone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

3T3-L1 Cells
Adipocytes / cytology
Adipocytes / drug effects*
Adipogenesis / drug effects
Animals
Lipase / metabolism
Mice
Molecular Structure
Pulse Radiolysis
Rotenone / analogs & derivatives*
Rotenone / chemistry*
Rotenone / pharmacology*
Rotenone / radiation effects
Structure-Activity Relationship

Substances

Rotenone
Lipase